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Chronic Kidney Failure Causes

Chronic kidney failure is the end stage of various chronic kidney diseases and it will progress in the end into anemia without timely and proper treatments. Chronic renal failure is one common serious disease and in severe conditions will threaten patients’ life, therefore effective treatments should be sought as early as possible.

To ensure the curative effects, we need first make clear what is the underlying cause of renal failure so that the treatments can be more targeted and effects and the course of treatments will be much shortened. What is more, important, the best treatment period will not be missed with accurate and thorough diagnosis of kidney failure causes.

There are a variety of causes of chronic kidney failure and they can be classified into the following aspects.

Glomerular lesions

Glomerular disease is one common cause of renal failure. It includes primary and secondary glomerular nephritis such as IgA nephropathy, focal segmental glomerulosclerosis, diabetic nephropathy, hypertensive renal arteriolosclerosis, lupus nephritis, purpura nephritis, etc.

Tubular interstitial lesions

They belong to renal tubular diseases including chronic pyelonephritis, chronic uric acid nephropathy, obstructive nephropathy (such as ureteral obstruction, countercurrent kidney disease and stones in the kidneys and urinary tract, etc) and renal damaged due to intake of medicines and drugs that have renal toxicity such as painkiller, heavy metals, antibiotics, some anti-inflammatory agents, medical contrast agent, antitumor drugs and some Chinese medicines, etc.

Renal vascular diseases

Renal damages can be roughly classified into renal parenchymal impairment and renal vascular impairment according to the location of renal damages. Common renal vascular lesions include hypertensive nephropathy, renovascular hypertension, small artery sclerosis, etc.

Hereditary renal disease

Such as polycystic kidney disease, Alport syndrome and hereditary nephritis, etc.

Infectious renal diseases

Include chronic pyelonephritis, renal tuberculosis, etc.

Metabolic disorders

Such as diabetic nephropathy, gouty nephropathy and amyloid nephropathy, etc.

Whatever the cause of renal failure is, there are some common pathogenesis. Renal impairment and loss of kidney functions will cause over stress and strains to the healthy renal tissues. Long time overload work will damage more and more renal functional units and lower GFR. Once the vicious circle is formed and when GFR falls below 25%, it will be very hard to reverse renal damages and recover kidney functions even though the underlying cause is removed, therefore early diagnosis and timely treatment is very necessary for chronic kidney failure patients.

Different treatments will be offered according to the underlying cause of renal failure. The first step is to remove the underlying cause and alleviate clinical symptoms and discomforts and then more effective treatments and measures should be taken to repair damaged renal tissues so as to prevent further deterioration of renal damages and protect kidney functions.

Polycystic Kidney Disease(PKD)

Nephrotic Syndrome

IgA Nephropathy

Diabetic Nephropathy

Chronic Kidney Disease(CKD)

Focal Segmental Glomerulosclerosis