High creatinine levels are often associated with kidney disease. In many instances, the same drugs that are used to treat kidney disease also cause rise in creatinine levels. Now let’s learn about what the medications are.
ACE inhibitors are used to treat hypertension. The common ACE inhibitors include enalapril, fosinopril, lisinopril and ramipril. The rise in creatinine level is usually observed two weeks or less after starting taking this family of drugs. However, it is not accompanied by other symptoms of renal failure unless the renal function is less than 30%. This rise in creatinine level is transient and disappeared after the patient stop taking the drug.
Though ACE inhibitors belong to the medications which can cause the rise in creatinine level, they continue to be a good choice for kidney disease patients, that is because they minimize other symptoms of kidney disease.
Cyclosporine can also cause rise in creatinine level. Cyclosporine is an immunosuppressant that is given to prevent rejection of transplanted organs or to help kidney disease patients to lower urine protein. In some instances, it is given to treat autoimmune disorders.
Some researchers concluded that even six months’ use of cyclosporine at a maximum dosage of 10mg/kg can lead to an irreversible loss of kidney function. Doctors must balance the benefits of minimizing organ rejection against the risk of organ failure when prescribing this drug.
Moreover, common over-the-counter drugs such as ibuprofen as well as prescription drugs do not affect creatinine levels in healthy people may cause rise in creatinine levels in patients with compromised renal function.
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