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Standardization of Measuring Creatinine

2013-02-10 11:20

There are at present about 10-20 million chronic kidney disease patients in the United State and its incidence is in rapid growth. CKD is dormant and most cases will enter into end stage renal disease after decades of years.

Therefore it is very urgent to arouse enough attention and awareness of the severity of kidney disease and promote early diagnosis and treatments for CKD so as to effectively slow down the decline rate of kidney functions and greatly improve its prognosis.

At present the commonly used indicator for kidney function is creatinine. Thought many factors can affect creatinine test, the serum creatinine level is relatively stable and therefore it is widely adopted in clinic. The standardization of creatinine test can enable more reliable and accurate measuring of kidney functions.

It is recommended that GFR (glomerular filtration rate) should be reported at the same time of measuring creatinine. GFR can be calculated with serum creatinine as well as taking into accounts the patients’ age, gender, race and body weight.

The following are equations for calculating GFR by yourself.

For serum creatinine that is obtained with IDMS reference.

GFR=175*(creatinine)-1.154*(age)-0.203*(0.742 for women)*(1.212 for African American)

For creatinine levels that are not obtained through IDMS reference.

GFR=186*(creatinine)-1.154*(age)-0.203*(0.742 for women)*(1.212 for African American).

GFR is a practical and simple way to distinguish severity of renal damages. Early detection and diagnosis can make some diseases to be cured and some to be much slowed down. All these are important for both patients and physicians.

The following are the reference for measuring kidney functions with GFR level.

GFR is more than 90: stage 1 chronic kidney disease and there are almost normal renal functions and there is no clinical symptoms.

GFR is between 89-60: stage 2 CKD and there is mild damages of renal functions and there are abnormalities in blood test, urine test and imaging studies.

GFR is between 59-30: stage 3 CKD and there is moderate reduction of renal functions.

GFR is between 29-15: stage 4 CKD and patients will begin to prepare for dialysis or kidney transplant.

GFR is less than 15: stage 5 CKD and also known as end stage renal failure. Dialysis and kidney transplant will be needed.

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