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Must High Creatinine In Kidney Failure Develop Into ESRD

2019-06-13 10:00

Kidney Failure,High Creatinine,ESRDUremia is the end-stage manifestation of Kidney Failure, which means that the damage of renal function has exceeded 90%. With the loss of renal function, the level of endotoxin in the body increases, which leads to the increase of serum creatinine, uric acid, urea nitrogen and other indicators.

Thus, it is not the accumulation of toxins caused by creatinine elevation that leads to uremia, but the deterioration of detoxification ability caused by the damage of renal function itself. More and more toxins accumulate in the kidney.

Therefore, nephropathy should prevent the occurrence of uremia, not only to reduce creatinine, but also to protect the remaining renal function.

To a large extent, the residual renal function is very important for the prognosis of patients.

These indicators play a decisive role in the final development of renal function.

1. Reducing Proteinuria - Maintaining Filtration Function

Proteinuria is also one of the indicators that kidney disease patients pay more attention to. Unlike creatinine, proteinuria affects the prognosis of the kidney disease. Popularly speaking, for most kidney diseases, the higher the proteinuria, the greater the risk of renal failure. Therefore, the treatment of proteinuria should be emphasized whether in the early stage or the end stage of nephropathy.

Protein leakage indicates that there are two problems in the kidney. The first one is that the glomerulus is damaged and the pore of the filtration membrane is enlarged, which leads to the leakage of macromolecule proteins and the frequent occurrence of immune inflammation in the two kidneys, leading to protein leakage.

Protein-lowering therapy should start from these two aspects, eliminating inflammation, through hormones, immunosuppressants and other drugs, often can play a positive role. In terms of repairing damaged glomeruli, some lightly damaged tissues can be repaired, but the necrotic glomeruli can not be reversed.

Chinese medicine therapy can accelerate blood circulation, remove necrotic tissue in time, create a good living environment for the remaining glomeruli, and protect the residual renal filtration function.

2. Reducing Blood Pressure and Lipid Level to Guarantee Kidney Oxygen Supply

Increased blood pressure and lipid levels will affect the whole body's blood flow, especially the kidney as a filter and detoxification organ. Once the blood flow in the kidney is insufficient, it will cause insufficient blood supply and oxygen supply of kidney cells, resulting in impaired renal function.

Therefore, after the occurrence of renal insufficiency, kidney disease patients s must pay attention to the monitoring of blood pressure, blood lipid and other indicators. After stage 3 of nephropathy, 70% of patients will have hypertension, and some patients themselves have hypertension.

For the treatment of hypertension and hyperlipidemia, two key points are: one is to insist on taking antihypertensive and antihyperlipidemic drugs. The first choice of antihypertensive drugs is pril or sartan drugs, lipid-lowering drugs are statins. These three drugs also have the effect of reducing protein and delaying renal function, so they are the first choice. Among them, pril or sartan drugs have potassium-raising and creatinine-raising effects. Patients with renal insufficiency and creatinine higher than 265 should be cautious.

Cooperate with diet control. Adhere to the principle of low salt and low fat diet, alleviate symptoms at the same time, but also reduce the metabolic burden of the kidney, to create a better living environment for the kidney.

3. Prevention and treatment of metabolic disorders of high potassium, calcium and phosphorus - stabilization of electrolyte environment

Kidney is an organ that regulates the balance of water, electrolyte and acid-base in the body. Therefore, when renal function fails to function properly, there will inevitably be imbalance of water, acid-base metabolism and electrolyte disturbance. Because of the compensatory nature of the kidney, the metabolic disorders of high potassium, calcium and phosphorus, metabolic acidosis and other electrolyte disorders began to appear slowly in the period of renal failure.

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