Creatinine can be divided into serum creatinine and urine creatinine. Usually it refers to serum creatinine when we say creatinine and it indicates the level of creatinine in the blood and is commonly adopted in clinic to measure patients’ kidney functions.
The normal creatinine level is 53-140 μmoI/L and higher than normal creatinine can cause a series of symptoms.
1. Edema (swelling)
Edema will begin with the eyelids and some patients may begin with lower limbs. In serious conditions, it will involve the whole body and cause chest water and ascites.
2. High blood pressure
High blood pressure is one of the signs of high creatinine.
3. Abnormalities in urination including urinary urgency, urinary frequency and urinary pain.
4. Dull back pain
In some conditions such as the underlying cause of kidney failure is renal cystic diseases, kidney stone or obstructive renal diseases, patients will suffer from back pain.
Hematuria is blood in urine
Daily urine output might exceed 2500ml and it is called diuresis.
7. Oliguria or anuria. Oliguria is less than 400ml urine volume and anuria is less than 100ml.
8. Bubbles in urine.
Bubbles in urine might indicates proteinuria and urinary protein qualitative test can confirm it.
If serum creatinine continues to increase, dialysis will be recommended when it rises to a certain level or there are some severe index of dialysis.
Actually the above mentioned symptoms and discomforts are not caused by high creatinine which itself is a clinical manifestation and abnormal indicator of kidney failure. Therefore it should not be the ultimate goal to lower creatinine, more effective treatments should be sought to repair kidney damages and improving kidney functions. When kidney functions are improved, excessive creatinine and other metabolic wastes and toxins can be cleared from the blood and serum creatinine can drop accordingly and naturally.
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