What medicines can cause elevation of creatinine level? Serum creatinine is usually measured to reflect kidney condition in clinic, as kidney is the major organ to expel creatinine out of the body. High creatinine level always means poor kidney condition and in our daily life, for people with kidney disease and elevated creatinine level, they should be aware of the following medicines, as they can also cause elevation of creatinine level.
1. Chemotherapy drugs
Several chemotherapy drugs like Cisplatin, Carbplatin, Carmustine, Mitomycin and Methotrexate may cause kidney damages and thus elevate creatinine level. For this reason, it is of great importance for kidney disease patients to check their creatinine level to make sure their kidneys can handle these drugs.
2. Angiotensin Converting Enzyme Inhibitors
Angiotensin Converting Enzyme inhibitors (ACE inhabitors) are commonly used to deal with high blood pressure and prevent heart problems. Many kidney disease patients are familiar with ACE inhibitors, as they may need these medicines to control their blood pressure. ACE inhibitors are helpful in treating kidney disease to some extent, but some patients with impaired kidney function, such as narrowing of the arterial vessels in the kidney, are not suggested to take these medicines as these medicines can cause further kidney damages and raise further elevation of creatinine level.
Cyclosporine is an immunosuppressant that can be used to prevent rejection of transplanted organs, lower urine protein and treat autoimmune disorder. Similar with ACE inhibitor, although cyclosporine shows good effects in treating kidney disease, it can also cause elevation of creatinine level.
Antibiotic is another kind of medicine that can cause elevation of creatinine level. In our daily life, the most common antibiotics that need to be avoided by kidney disease patients include Amphotercin B, Gentamycin and Vancomycin and so on.
If some painkillers like Ibuprofen, Aspirin and Naproxen are consumed for a long time, kidney failure and high creatinine level will be caused. For this reason, kidney disease patients should avoid taking painkillers without consulting doctors in advance.
Diuretics like furosemide (Lasix) are also believed to be able to cause elevation of creatinine level as they can cause the kidney’s to work overtime trying to compensate.
The above is the introduction about several medicines that can cause elevation of creatinine level. As they can cause damages on kidney, no matter we are patients of kidney disease or not, we should be careful about the usage of them.
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