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What Are The Causes Of Diabetic Nephropathy

2018-09-06 10:15

Diabetic Nephropathy,CausesGlucosuric nephropathy is one of the most common cases of diabetes mellitus patients, a complication of diabetes. Many patients hear of this disease, are very afraid, or even feel that it is impossible to cure, such a pessimistic mood is not good, sick should be a good positive treatment, as long as adhere to and find the best treatment.

Men have a higher incidence of diabetic nephropathy than women; studies from the United States have found that African and Mexican descendants are more prone to diabetic nephropathy than whites in the same living environment; and certain families of the same race are more prone to diabetic nephropathy, all suggesting genetic factors. Microalbuminuria occurs in 40%-50% of type 1 diabetes mellitus and diabetic nephropathy occurs in only 20%-30% of type 2 diabetes mellitus during the observation period, suggesting that genetic factors may play an important role.

Early diabetic nephropathy can be observed renal hemodynamic abnormalities, manifested by glomerular hyperperfusion and high filtration, renal blood flow and glomerular filtration rate (GFR) increased, and increased protein intake increased more significantly.

Hyperglycemia mainly results in kidney damage through renal hemodynamic changes and metabolic abnormalities. The mechanism of kidney damage caused by metabolic abnormalities mainly includes: (1) local glycometabolism disorder in kidney tissue, which can form glycation end products (AGES) through non-enzymatic glycosylation; (2) activation of polyol pathway; (3) diacyl glycosylation; Activation of glycerol protein kinase C pathway; abnormal metabolism of hexosamine channel. These metabolic abnormalities not only participate in early hyperfiltration, but also promote the thickening of glomerular basement membrane (GBM) and accumulation of extracellular matrix.

Almost any type of diabetic nephropathy is associated with hypertension. Hypertension in type 1 diabetic nephropathy occurs in parallel with microalbuminuria, and in type 2 diabetic nephropathy occurs often before. The situation of blood pressure control is closely related to the development of diabetic nephropathy.

There are many abnormal metabolism of vasoactive substances in the development of diabetic nephropathy. These include metabolic abnormalities such as RAS, endothelin, prostaglandin and growth factors.

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