Creatinine level is a reliable indicator of kidney disease and kidney problem. The production of creatinine is relatively stable and it is mainly removed from the blood through the kidneys. It is not a very good indicator of early stage renal failure because it will remain in the normal range until more than 40-50% kidney functions are lost. For end stage renal failure patients, it is widely used to reflect severity of renal damages and remaining kidney functions.
High creatinine and kidney functions
Nearly all the creatinine will be discharged with urine through the filtration of the kidneys. End stage renal failure patients have less than 15-10% kidney functions and the severely damaged kidneys can not function well to efficiently remove creatinine and other metabolic wastes and toxins from the blood. Creatinine will accumulate in the body and cause elevated serum creatinine levels and a series of symptoms. All end stage renal failure patients will develop high creatinine levels.
Only when renal functions are improved can high creatinine be treated effectively from the root.
Kidney function and GFR
Creatinine can be used to calculate GFR (glomerular filtration rate). GFR can reflect how the kidneys filter wasteful products from the blood. Renal failure can be divided into 5 stages by calculating GFR. For end stage renal failure patients, their GFR has been fallen below 15 and it means that more than 85-90% kidney functions have been lost.
High creatinine and GFR
Actually it is recommended that both creatinine level and GFR should be considered while measuring the extent of kidney disease. Often many renal failure patients do not know much about GFR. It can be calculated by your doctor or by yourself with your creatinine level, race, gender, age. It is very simple but very useful for end stage renal failure patients.
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