Mesangioproliferative glomerulonephritis is a primary glomerular disease that is characterized by proliferation of glomerular mesangial cells and the buildup of extracellular matrix in the mesangial areas. For some patients, it can slowly progress into ESRD (end stage renal disease) without timely or effective treatment.
Due to different pathological changes and clinical manifestations, the prognosis and course of the disease vary a lot from patient to patient. Most patients have good prognosis and some few cases can achieve spontaneous remission. While some patients will experience progressive decline of kidney functions and in the end progress into renal failure.
Mild cases can only have hematuria or proteinuria and severe cases can have the symptoms of nephrotic syndrome. About 30-100% patients have microscopic hematuria, 20-30% have recurrent gross hematuria (the blood in urine can be seen with naked eyes), 30% patients have slightly increased blood pressure. In the early stage of the disease, kidney functions can still be normal and in the later stage 10-25% patients will experience loss of kidney functions.
Many factors can affect the progression and prognosis of mesangioproliferative glomerulonephritis. Generally, patients that only have hematuria usually will not progress into ESRD; those that have long term small amount of proteinuria with or without hematuria have long course of disease; those that have massive protein in urine enters into renal failure much earlier than other conditions; patients of massive proteinuria with high blood pressure will develop renal failure after years; the prognosis is considered to be very poor if patients have high blood pressure and renal dysfunction.
It is very important for mesangioproliferative glomerulonephritis patients to avoid low blood volume because it can cause decreased blood flow to the kidneys or even lead to acute renal failure.
Besides ESRD, patients should also have early and effective treatment for other complications such as infections, thrombosis, metabolic disorders of proteins and fats. Because other complications instead of renal failure is often the main cause of death for kidney disease patients.
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