IgA Nephropathy is a glomerular disease and we call it IgA Nephropathy as it is marked by large amounts of IgA or IgA immune complexes in mesangial area. IgA is the abbreviation of immunoglobulin A and the content of it in our blood is only second to IgG. When our immune system is abnormal or when specific antigen invade our body, our body produce large amounts of IgA antibody which can combine with antigen and form IgA immune complex. IgA immune complexes or IgA circulate with our blood and they are normally discharged by our kidney. However,when our immune system is abnormal, they will deposit in our kidney, which can cause inflammatory response directly. Inflammatory response is harmful for our renal tissues and IgA Nephropathy is diagnosed when our kidney is damaged by inflammatory response.
Without clearing IgA immune complexes or IgA antibody away from kidney, inflammatory response lasts and cause further kidney damages. Kidney failure occurs when kidney fails to function properly. Whereas, if we can remove IgA immune complexes or IgA effectively in early stage, kidney function will be protected greatly and also IgA Nephropathy stops to deteriorate to kidney failure. Therefore, a effective management for IgA Nephropathy is very helpful for preventing kidney failure.
However, as many patients have no idea about how IgA Nephropathy is formed in our body, they do not know how to treat IgA Nephropathy effectively. They attach no importance to their kidney problem and just take some medicines to control symptoms. Tight control of symptoms is helpful for slowing down IgA Nephropathy, but it is not effective enough to stop IgA Nephropathy. If we want to avoid kidney failure with IgA Nephropathy, we must normalize immune system, control symptoms and meanwhile clear IgA immune complexes or IgA antibodies away from kidney. Only in this way, can patients with IgA Nephropathy be totally free from kidney failure.
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