Is IgA Nephropathy Hereditary? My dad has Stage 5 IgA Nephropathy and he needs a transplant. I want to become the donor, and to find out if I could possible develop the same disease. Can I donor my kidney to my dad? Is kidney transplant the only choice for Stage 5 IgA Nephropathy?
IgA Nephropathy is a result of predominant IgA building up in the glomerular mesangium and attacking it. Even though there may be a genetic predisposition towards IgA Nephropathy (IgAN), more than 90% of IgAN isn’t familial. This means IgA Nephropathy isn’t hereditary in most cases.
In clinical, IgA Nephropathy is an autoimmune disease that is commonly due to immunodeficiency instead of genetic factors. If untreated effectively in the early stage, IgA Nephropathy may progresses to stage 5 or kidney failure where patients have to consider kidney transplant.
However, compared with people with other kidney disease, IgAN patients have a higher recurrence rate after kidney transplant. This is because IgA deposition can occur in the transplanted kidney again.
From the above analysis, we can know kidney transplant isn’t the best choice for people with IgAN. To treat this disease from the root cause, the most effective treatment should be the one that can not only eliminate these immune complexes thoroughly but also improve kidney function.
According to this requirement, quite a number of kidney experts work together to strive to create a new treatment. Fortunately, they indeed do it. A brand new remedy, called Immunotherapy, is formed in recent years. On on hand, it uses different blood purification technologies to purify blood to so as to remove IgA deposition from the body. On the other hand, it absorbs the essence of herbal medicines that are effective on prompting the self-repair of damaged kidney cells. With these two effects, immunotherapy can help treat IgA Nephropathy successfully.
IgA Nephropathy is commonly extragenetic, but a familial clustering of IgA Nephropathy indeed appears in about 10% of cases. If you or your family members have this disease, don’t pin too much hope on kidney transplant, since the recurrence rate is so high. If you have any question, welcome to leave a message to kidney experts at kidneycares community.
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