The kidneys are chiefly responsible for discharging toxins out of bloodstream. When kidneys are poorly functioning, the toxins gradually accumulate in bloodstream. Elevations of those toxins are not only indicators for damaged kidneys, but also can increase one’s chance of some severe complications.
Blood urea nitrogen (BUN)
Blood urea nitrogen (BUN), a metabolic product of proteins, is normally expelled into urine by the kidneys. Elevation of BUN can indicate reduction of glomerular filtration rate (GFR).
Creatinine is a metabolic product of muscle activities. It is a more specific indicator than blood urea nitrogen (BUN) for glomerular filtration rate (GFR).
Uric acid (UA)
Uric acid, the end product of purine, usually increases after kidney function declines or gout occurs.
BMG, or beta 2 microglobulin will increase when kidney function declines or there is tumor. BMG is a middle molecular toxic substances. In kidney disease patients, elevation in BMG can increase the patients’ risk of Renal Amyloidosis.
CycC is an ideal indicator for glomerular filtration rate (GFR). It has special advantages in children and kidney disease patients. Similar to BMG, CycC is also a middle molecular substance; its rise can further increase chances of Amyloidosis.
RBP(retinol binding protein) is a toxic substance that combines with proteins. It rises much faster than creatinine when Glomerular Filtration Rate declines. RBP declines when combined liver disease or malnutrition occurs.
HCY (hemocysteine) is a toxin that combines with proteins. It is an independent risk factor for cardiovascular diseases. Buildup of HCY in blood in patients with chronic kidney failure can increase one’s chances of cardiovascular diseases.
IL-6(interleukin 6) is an important indicator for acute or chronic inflammations. Elevation in IL-6 is related to severe complications of kidney diseases, including cardiovascular diseases, malnutrition, Uremic anemia, etc.
PTH (parathyroid) is a middle molecular substance. Elevation in PTH is seen in patients who have combined bone diseases.
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