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Factors Affecting Life Span of Transplanted Kidney

2013-01-03 16:48

Dialysis and kidney transplant are the major treatments for end stage renal disease patients. Many patients will first take dialysis to sustain their life and when dialysis fails, they would consider kidney transplant. However kidney transplant does not means complete cure of the disease and patients still need to pay more attention in their daily life besides regular intake of prescribed medicines and follow-up checks.

There are many factors that can affect the life span of the transplanted kidneys and generally speaking, the survival rate after one year is 85%, it is 60% after 5 years and it is 1% after 10 years.

The main issues that kidney transplant patients should concern are rejections, virus infections and cardiovascular diseases.

Thought survival rate within one year is obviously improved, long term intake of these drugs can cause renal poison, damage renal functions and increase risk of infections. These side effects can lead to chronic pathological changes and affect long term survival rate of kidney transplant. Therefore how to design ideal immunosuppressive treatment, what is the proper and effective dosage and how to adjust its use are extremely important for kidney transplant patients.

However dosage reduction or stopping taking immunosuppressant without doctor’s permission can cause severe rejections and affect the life span of the transplanted kidney. Therefore have regular routine tests and constant consultation once there is any discomforts or abnormality.

Another factor affecting survival rate of kidney transplant is high blood pressure can cause great damages to both patients and the transplanted kidney. High blood pressure can increase glomerular capillary pressure, cause glomerular arteriosclerosis and damage the basement membrane and kidney function.

Hyperlipemia is another important factor. Due to long term intake of hormones and immunosuppressant, patients have high risk of hyperlipemia. The incidence of high cholesterol is 30%-67%, the incidence of hyperlipemia is 20-33%. There are about 40% kidney failure patients die of cardiovascular disease and occlusive vascular diseases.

Therefore early prevention, healthy life style and regular check of kidney functions are very important and necessary for kidney transplant patients to have a longer life expectancy.

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