Donor-specific Antibodies Increase Rejection in Kidney Transplant

It has been found by a study performed by doctors from Columbia University Medical Center that even very low level of donor-specific antibodies will increase the risk of organ rejections and kidney failure after the transplantation. The antibody-mediated rejection and kidney failure is almost doubled.

If the transplant recipients have had transplant operation or blood transfusion before, they often have certain antibodies that are against particular donor's kidneys which is better be avoided if more matching donors are available. These antibodies are called donor-specific antibodies.

It is hard to detect these antibodies with traditional tests. Some new tests called solid phase assays can find them even when their blood concentrations are very low.

So what is the significance of this study and finding? We know that the organ rejection is one major concern of many renal failure patients waiting for kidney transplant as well as the doctors. Patients have to take anti-rejection medicines for the rest of their life and suffer from suppressed immunity. What is more, the transplanted kidney has risk of failing once again. This study can help clinicians have better and more suitable matching of kidney donor and recipients. It can also help clinicians prescribe more effective immunosuppressant and reduce rejections after the surgery so as to increase the successful and survival rate of transplanted kidney.

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