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Why Polycystic Kidney Disease Cause Renal Failure

2013-01-05 09:48

Polycystic kidney disease is a hereditary renal disorder and the abnormal gene in PKD will pass to the following generations bothering patients and their families a lot.

Of cause, the biggest concern is will PKD cause renal failure. Unfortunately the answer to this question is yes . So why should PKD cause renal failure and how long will it take to develop renal failure from PKD.

Polycystic kidney disease is characterized by multiple cysts in the kidneys due to gene mutation. The size and number of the cysts will increase along with age. As a result, these fluid-filled cysts will occupy much space in the kidneys oppressing and replacing normal renal intrinsic cells and tissues. Damages of renal tissues will gradually reduce kidney functions and in the end progress into renal failure if left untreated.

In the early stage of PKD, there are only several cysts and they are still small in size, the kidney functions can be still normal. Most patients can remain normal kidney functions between 40-60 years old.

However the cysts will experience gradual growth and cause a series of symptoms, complications and decline of renal functions. Signs of early damage of renal function is increased urine volume due to urinary concentrating defect.

Once renal function is being affected, it will experience gradual decline and loss. The average decline rate of glomerular filtration rate is about 4.4-5.5ml/min and it takes about 10 years to progress into end stage renal disease since kidney functions began to decline.

How to prevent PKD from developing renal failure?

We know that there is no thorough cure for PKD at present, but patients should not wait passively for the coming of renal failure. There are a lot of things that can and should be done to slow down the progression into renal failure, alleviating pains and suffering, improving life quality and prolong life expectancy.

1. Early detection and diagnosis

We know that PKD has the feature of familial aggregation, therefore it is better that you go for renal imaging tests such as B ultrasound, CT or MRI to rule out the possibility if there is someone in your family that have the disease.

Prenatal gene diagnosis can know in advance weather the baby will develop PKD after he or she is born and this can help increase prepotency rate.

2. Early and effective prevention and treatments for complications

High blood pressure, urinary tract infection and cyst rupture are the common complications and they are also important factor for inducing and worsening renal functions. Timely and proper measures are very necessary for slowing down PKD progression.

3. Proper home nursing and cares

Home nursing and cares are equally important as medicines and treatments because PKD is a life-long disease and patients need to pay more attention in their daily life including diets, exercises and rests.

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