Kidneys have the functions to regulate water and electrolytes balances, filter and cleanse the blood, remove metabolic wastes and toxins outsides through urination, secrete hormones to build the bones and produce enough red blood cells.
Kidney failure is a chronically progressive disease. Since kidney disease usually can not be cured by itself, if left untreated, it will continue to become worse and worse and in the end cause irreversible and advanced renal damages and harms to the whole body.
When the kidney fails and loses most part of its functions, patient’s body will be filled with excessive water, electrolytes as well as many toxic wastes. On the other hand, the body will be lack of many useful substances such as proteins, red blood cells due to reduced production or too much loss in urine.
In the latter stage of kidney failure when there are advanced renal damages, the patients will have a series of disorders and imbalances which will not only affect the kidney functions but will involve nearly every part of the body. The body organs might be poisoned and damaged by wasteful products and many tissues and organs will become necrotic or impaired due to inadequate nutritions supply.
High creatinine and BUN
Elevated serum creatinine and blood urea nitrogen are very common among kidney failure patients because the diseased kidneys can not filter that much blood and it can not remove that much wastes from the blood. Creatinine, urea are not only the only wastes in the blood, there are many other wastes. These wastes and toxins will accumulate in the blood and circulate with the blood to every part of the body and cause harms to the whole body.
Besides fluid retention, electrolyte disorders, kidney failure can cause metabolic imbalances of protein, sugar, fat and vitamins. A series of symptoms such as fatigue, nausea, vomiting, anemia, etc can be caused. And the nutritional states of the body will be disturbed.
Besides, end stage renal failure patients often have symptoms and discomforts in cardiovascular system, respiratory system, gastrointestinal system, neuromuscular system, blood system, bones, etc. Some serious or even life-threatening illness conditions can develop such as heart failure, pulmonary failure, etc.
In a word, if left untreated, the patients will be very painful and their life is at risk at any time when illness conditions progress into the end stage.
It is recommended that timely and effective treatments are sought. The earlier the treatment is sought, the less sufferings and the better the prognosis.
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