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Kidney Failure And Protein Loss in Urine

2013-04-15 15:11

Almost all the kidney failure patients have serious protein loss in urine and many of them have the misconception that it is protein in urine cause their kidney failure. Actually, protein loss in urine is just one of the clinical manifestations of kidney failure and having a good management of it will help to improve prognosis.

How does kidney failure cause protein loss in urine?

Kidney perform filtration function through glomerular filtration membrane which is composed of glomerular endothelial cell, basilar membrane and glomerular epithelial. This membrane only allows protein with negative charge and a certain of molecular weight. Usually, only substances with negative charge and radius less than 14 like urea nitrogen and glucose can pass through this membrane. Because of serious limitation, only very small of protein can pass through glomerular filtration membrane. When these protein pass through filtration membrane and reach renal tubules, most of them will be reabsorbed. For kidney failure patients, protein loss can be caused by:

1. Damaged glomerular filtration membrane

When glomerular filtration membrane is damaged, some protein pass through it easily. Although renal tubule can help to reabsorb some of them, when the amount of protein is beyond the reabsorbing ability of renal tubule, they get out of our body with urine.

2. Damaged renal tubule

Glomerular filtration membrane can not help us preserve all the protein, which means some protein still can pass through filtration membrane in normal cases. These protein are finally reabsorbed by renal tubule; however, when function of renal tubule is affected, these protein will leak out with urine and thus form proteinuria.

How to manage protein loss in urine caused by kidney failure?

Good management of protein loss in urine helps kidney failure patients to improve prognosis. To remit protein loss effectively, kidney failure patients need to:

1. Limit protein intake and try to ingest some high quality protein like fish, lean meat and egg white.

2. Having tight control about kidney failure symptoms, as these symptoms may cause further kidney damages.

3. Repair kidney damages to improve kidney function. As long as kidney function is improved, protein loss will be remitted at the same time.

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