Kidney failure patients often have a series of abnormalities in their laboratory tests such as high uric acid, high serum creatinine and high blood urea nitrogen (BUN). Kidneys have the functions to remove excess water, electrolytes, minerals as well as metabolic wastes and toxins from the blood. When renal tissues are damaged and renal functions are affected, some wastes and toxins can not be removed, therefore high uric acid is often one sign of kidney failure.
The amount of uric acid that is produced and excreted each day is almost the same. 2/3 of the uric acids are discharged from the kidneys and 1/3 is discharged from intestinal tract. 1/3 uric acids in the body comes from foods and 2/3 is synthesized by the body. Therefore if the production of uric acids is stable, high uric acid in the blood is due to hindered excretion from the kidneys and gastrointestinal tract.
Normal level of uric acid for male is 149-416umol/L and for female it is 89-357umol/L. Since kidneys are the main organs to filter uric acid from the blood, it is more likely to be kidney problem when uric acid is higher than normal level.
Often high uric acid will occur in case of kidney disease and kidney failure. When the clearance rate of creatinine is below 5%-20%, patients will have hyperuricemia (high uric acid).
If left untreated, high uric acid will in turn worsen renal damages . The higher the uric acid level is, the more incidence to develop renal failure. Early and effective lowering high uric acid can delay or even prevent ESRD (end stage renal disease).
Treatments for lowering high uric acid
Controlling high uric acid can effectively prevent hyperuricemic nephropathy and slow down decline rate of kidney functions.
Diets: high uric acid patients should avoid animal offals, broth, peas, lentils, alcohol, tobacco, strong tea, coffee, spicy foods; have more foods that contain rich vitamin B1 and vitamin C.
Drugs. If diets alone can not help, patients can have some drugs under the doctor’s permission and guidance to inhibit the production of uric acid or promote its excretion such as allopurinol, etc. Drink more water while taking these drugs and have regular check of kidney functions because some drugs have potential renal damages.
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