In kidney failure, Vasopressin analogues are usually used to increase urine osmolarity and decrease water excretion. It plays an irreplaceable role for kidney failure patients owing to its treatment effects.
Vasopressin analogues have two primary functions which are to retain water in the body and to constrict blood vessels. And in cases of kidney failure, it works in the following ways:
1. Renal tubule, one of the kidney tissues, plays an important part in producing urine. They reabsorb the nutritions and fluids filtered by glomeruli. However, when kidney tubules are damaged, they fail to display their reabsorption ability and urine is poorly concentrated. With vasopressin analogues, water permeability of distal tubule and collecting duct cells in the kidney can be increased, and thus allowing water reabsorption and excretion of more concentration urine.
2. Vasopressin analogues regulates the cell surface expression of urea transporters, which can increase permeability of the inner medullary portion of the collecting duct to urea. Also, it facilitates its reabsorption into the medullary interstitium, as it travels down the concentration gradient created by removing water from the connecting tubule cortical collecting duct and outer medullary collecting duct.
Vasopressin is just a commonly used medication in kidney failure. Although it is helpful in treating kidney failure, it can not cure kidney problem radically. Kidney failure is a serious illness condition and can not be cured, as the dead kidney tissues can not be revived at all. For kidney failure patients, the best treatment method is to bring all the symptoms under control, protect residual kidney tissues and repair these injured kidney intrinsic cells. If these purpose can be achieved by some medical measures, kidney failure patients will receive obvious treatment effects.
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